Ra. Barrow et al., TOTAL SYNTHESIS OF CRYPTOPHYCINS - REVISION OF THE STRUCTURES OF CRYPTOPHYCIN-A AND CRYPTOPHYCIN-C, Journal of the American Chemical Society, 117(9), 1995, pp. 2479-2490
The convergent total synthesis of cryptophycins C and D is described.
It has been shown that in both natural products the absolute configura
tion of the alpha-amino acid corresponds to the D-series. The structur
al assignment for cryptophycin C has been corrected to reflect this fa
ct, Since the structure of cryptophycin A has been correlated to crypt
ophycin C, the chloro-O-methyltyrosine unit in cryptophycin A has the
D-configuration.