POOR RENAL UPTAKE OF TC-99M DMSA AND TC-99M MDP IN A PATIENT WITH FANCONI SYNDROME AND NEAR NORMAL GLOMERULAR-FILTRATION RATE

The authors present a patient with Fanconi syndrome who demonstrated p oor renal uptake of Tc-99m DMSA and high urinary concentration of the tracer. Tc-99m DTPA imaging was normal and the creatinine clearance wa s only minimally decreased. These findings suggest that Tc-99m DMSA ma y be accumulated in the kidney by glomerular filtration and subsequent tubular readsorption. A Tc-99m MDP bone scan showed faint renal uptak e, as well as diffuse high skeletal uptake, particularly in the spine, demonstrating that the metabolic bone disease associated with Fanconi syndrome can be one of the causes of poor renal visualization on a bo ne scan.