ENHANCEMENT OF HEMATOPOIETIC UPTAKE BY GRANULOCYTE-COLONY-STIMULATINGFACTOR IN GA-67 SCINTIGRAPHY

The authors report on two non-Hodgkin's lymphoma cases which showed ma rkedly enhanced Ga-67 uptake of granulopoietic area induced by recombi nant human granulocyte colony-stimulating factor (rhG-CSF) administrat ion. The rhG-CSF is a newly developed agent for reduction of infection s, which stimulates the proliferation and differentiation of granulopo iesis. Use of rhG-CSF is becoming increasingly frequent because the in dications are so broad that most patients with intensive chemotherapy for malignancies benefit from undergoing this treatment. In this study , the results of the two cases were: 1) G-CSF enhanced the accumulatio n of Ga-67 citrate in the granulopoietic area; 2) the marked uptake of red marrow looked like involvement; and 3) in contrast, the involved area became relatively ''cold.'' These findings should be considered i n the interpretation of Ga-67 scintigraphy.