PREDICTORS OF DISTANT RECURRENCE IN CLINICAL STAGE-I OR STAGE-II ENDOMETRIAL CARCINOMA TREATED BY COMBINATION SURGICAL AND RADIATION-THERAPY

A retrospective analysis of 201 patients with clinical Stage I or II e ndometrial carcinoma treated by combined surgery and radiation therapy from January 1976 to December 1992 is reported. The aim of the study was to determine predictors, if any, for distant recurrence. Twenty-ei ght patients (13.9%) in our series developed a recurrence. The most co mmon sites were peritoneal carcinosis (28.6%), bones (28.6%), and lung s (21.4%). Seventy-eight percent appeared within 3 years, and actuaria l survival rates at 12, 36, and 60 months after recurrence were 39.2, 14.2, and 7.1%, respectively. An analysis of predictive factors signif icant for the development of distant recurrence was performed. Signifi cant factors by univariate analysis were age (P = 0.019), stage (P = 0 .02), grade (P = 0.014), depth of myometrial invasion (P = 0.007), lym ph node involvement (P < 0.001), and peritoneal cytology (P = 0.006). A multivariate analysis of these variables showed that lymph node invo lvement was the strongest predictor for distant recurrence. (C) 1997 A cademic Press