Zf. Zhang et al., RISK-FACTORS AND P53 NUCLEAR OVEREXPRESSION IN EARLY-STAGE INTESTINAL-TYPE ADENOCARCINOMA OF THE STOMACH, Cancer detection and prevention, 19(2), 1995, pp. 156-164
In order to investigate the relationship between altered patterns of p
53 expression and risk factors for stomach cancer, we have analyzed a
group of 35 patients with early stage intestinal-type adenocarcinoma o
f the stomach. We assessed p53 nuclear overexpression by immunohistoch
emistry, using monoclonal antibody PAb 1801, and identified 15 out of
35 patients (43%) displaying nuclear overexpression of p53 protein. Si
gnificantly elevated odds ratios (O.R.) were observed for greater body
mass index (highest quartile versus lowest quartile: O.R. = 7.9; 95%
confidence interval (CI): 1.1 to 56.1) and younger age (< 60 vs. great
er-than-or-equal-to 70 years: O.R. = 10; 95% CI, 1.43 to 50). The odds
ratio for p53 overexpression in cigarette smokers was 2.8 (95% CI: 0.
7 to 11.6) but not statistically significant. These data indicate that
p53 mutations may be involved in the early stages of gastric carcinog
enesis, especially in the development of intestinal-type adenocarcinom
a.