AN ANALYSIS OF 5-(P-HYDROXYPHENYL)-5-PHENYLHYDANTOIN INDUCED PERTURBATIONS IN THE 200-400NM REGION

It is shown that the presence of phenytoin, an anticonvulsant drug, in the human serum (HS) leads to perturbation of its UV absorption spect ra. The relations between the absorption spectra near 230 and 280 nm a nd hydrogen bond formation were considered. Spectral, phenytoin induce d changes, have been accounted for on the basis of Van der Waal's inte raction and Franck-Condon's strain.