GENETIC-POLYMORPHISM (ARG353-]GLN) IN COAGULATION-FACTOR-VII GENE ANDFACTOR-VII LEVELS (COAGULANT ACTIVITY, ANTIGEN AND BINDING ABILITY TOTISSUE FACTOR) IN 101 HEALTHY JAPANESE

We studied the frequency of the Msp I genotype (Gln353) for factor VII in 101 young healthy Japanese individuals, and the levels of factor V II-related procoagulant activity (FVII:c), antigen (FVII:ag) and bindi ng ability to tissue factor (FVII-TF binding). The frequency of the al lele coding for the factor VII Gln353 was 0.05 among this group. Indiv iduals with genotype M1M1 had an FVII:c of 103.52 +/- 17.85% (mean +/- SD), FVII:ag of 102.50 +/- 18.42% (mean +/- SD) and FVII-TF binding o f 101.03 +/- 22.22% (mean +/- SD). Triglyceride levels of subjects wit h the M1M1 genotype were 84.34 +/- 44.97 mg dl(-1) (mean +/- SD). FVII :c (50%), FVII:ag (45%) and FVII-TF binding (36%) from an individual w ith the M2M2 type was the lowest, with a triglyceride value of 39 mg d l(-1). On the other hand, individuals with the genotype M1M2 had an FV II:c of 75.57 +/- 9.61% (mean +/- SD), FVII:ag of 72.43 +/- 8.54% (mea n +/- SD) and FVII-TF binding of 68.14 +/- 14.91% (mean +/- SD). FVII: c, FVII:ag and FVII-TF binding in individuals with the M1M2 and M2M2 g enotypes were significantly lower than those in individuals with the M 1M1 genotype.