The present study was designed to assess the anxiety profile of the se
lectively bred alcohol-preferring sP and alcohol-nonpreferring sNP rat
s. Rats were offered either water (ethanol-naive rats) or a free choic
e of 10% (v/v) ethanol and water (ethanol-experienced rats) for 14 con
secutive days prior to the test. Spontaneous exploration of an elevate
d plus maze was used as a behavioral measure of anxiety. Ethanol-naive
sP rats spent less time in and made fewer entries into the open arms
of the maze than ethanol-naive sNP rats. These results suggest a highe
r innate degree of anxiety in sP than in sNP rats. Moreover, time spen
t in and number of entries into the open arms of the maze were higher
in ethanol-experienced than in ethanol-naive sP rats. This finding sug
gests that ethanol consumed voluntarily produces anxiolytic effects in
sP rats. The results of the present study are discussed in terms of (
a) anxiety as a genetic trait related to ethanol-preference in sP rats
and (b) self-medication of anxiety as a possible factor promoting vol
untary ethanol consumption in sP rats.