SYNTHESIS OF ALPHA-HYDROXY STATINE THROUGH A FACIALLY SELECTIVE OSMYLATION OF A CHIRAL ALPHA-AMIDO CROTONATE

Authors
DEE MF ROSATI RL
Citation
Mf. Dee et Rl. Rosati, SYNTHESIS OF ALPHA-HYDROXY STATINE THROUGH A FACIALLY SELECTIVE OSMYLATION OF A CHIRAL ALPHA-AMIDO CROTONATE, Bioorganic & medicinal chemistry letters, 5(9), 1995, pp. 949-952
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
9
Year of publication
1995
Pages
949 - 952
Database
ISI
SICI code
0960-894X(1995)5:9<949:SOASTA>2.0.ZU;2-5
Abstract
alpha-hydroxy statine 5 was synthesized by osmylation of amido crotona te 6 and incorporated into peptide framework 9, resulting in an active renin inhibitor; predicted stereochemical preferences for renin inhib ition were confirmed by x-ray analysis and biochemical determinations. The facial selectivity of the osmylation is consistent with the Vedej s model.