SYNTHESIS AND BIOASSAY OF A PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR, DEPHOSTATIN

Authors
YU LB MCGILL A RAMIREZ J WANG PG ZHANG ZY
Citation
Lb. Yu et al., SYNTHESIS AND BIOASSAY OF A PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR, DEPHOSTATIN, Bioorganic & medicinal chemistry letters, 5(9), 1995, pp. 1003-1006
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
9
Year of publication
1995
Pages
1003 - 1006
Database
ISI
SICI code
0960-894X(1995)5:9<1003:SABOAP>2.0.ZU;2-V
Abstract
The synthesis of natural product, dephostatin, is described. Both deph ostatin and N-methyl-N-nitrosoaniline are found to inactivate the homo geneous recombinant Yersinia and mammalian protein tyrosine phosphatas es in a concentration and time dependent manner.