GLYCOPROTEIN-B OF BOVINE HERPESVIRUS-1 BINDS HEPARIN

Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine h erpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns an d that gC-minus virus infectivity was inhibited by heparin. (C) 1995 A cademic Press, Inc.