HIGH-DOSES OF GONADOTROPINS HAVE NO DETRIMENTAL EFFECT ON IN-VITRO FERTILIZATION OUTCOME IN NORMAL RESPONDERS

Objective: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. Design: Retrospective an alysis of patients undergoing IVF therapy from 1990 to 1994 at our ins titution. Setting: Academic tertiary center. Patients: A homogeneous g roup of women that consisted of intermediate responders examined in th eir initial attempt and who received differing amounts of gonadotropin s were examined. Interventions: All patients were stimulated using a c ombination of a GnRH-agonist and FSH and hMG and were allocated into t wo groups, based on the amount of gonadotropin administered initially (four or six ampules). Main Outcome Measures: Implantation and pregnan cy (clinical and ongoing) rates were compared. Results: There were no significant differences between patients receiving high doses versus t hose patients receiving lower doses of gonadotropins with regard to im plantation and pregnancy rates. Conclusions: We conclude that high dos es of gonadotropins have no detrimental effect on IVF outcome in norma l (intermediate) responders.