NEUROIMMUNE INTERACTION IN THE GASTROINTE STINAL-TRACT

The enteric nervous system and immune system are integrated systems th at play an important role in the regulation of gastrointestinal functi ons. Recent studies suggest a bidirectional interaction between both s ystems. The relationship is based on the synthesis and release of neur opeptides from immune cells and the receptor-mediated alteration of ne rvous and immune functions by neurotransmitters and inflammatory media tors. The activity of the enteric nervous and immune system can be mod ulated by the central nervous system. These psycho-neuro-immuno-intera ctions are involved in gut inflammation, in functional bowel diseases and in the physiological control of gastrointestinal functions.