S. Borg et al., SYNTHESIS OF 1,2,4-OXADIAZOLE-DERIVED, 1,3,4-OXADIAZOLE-DERIVED, AND 1,2,4-TRIAZOLE-DERIVED DIPEPTIDOMIMETICS, Journal of organic chemistry, 60(10), 1995, pp. 3112-3120
Three series of heterocyclic dipeptidomimetics have been synthesized.
The compounds were designed as amino acid-glycine mimetics containing
1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,4-triazole ring systems, u
seful as building blocks in the synthesis of modified peptides. The he
terocyclic moieties were chosen according to their geometrical, electr
ostatical, and hydrogen bonding properties together with the synthetic
accessibility. The syntheses started with Boc-protected L-amino acids
(Ala, Gly, Asp, Phe, Ser, Arg, Cys, and Pro), and the reaction condit
ions were chosen to allow for the formation of products with high enan
tiopurity. The enantiomeric excess was determined by HPLC using chiral
stationary phases.