Background: Fungal sinusitis typically occurs in immunocompromised pat
ients. The authors report four cases of fungal sinusitis in immunocomp
etent young adults, all of whom had proptosis. Methods: The diagnosis
in all four patients was determined after orbital imaging and sinus bi
opsies. Results: All four patients required surgical removal of the fu
ngal source and antifungal chemotherapy postoperatively. Conclusion: P
atients with proptosis, ocular pain, or other symptoms suggestive of o
rbital cellulitis unresponsive to antibiotic treatment should undergo
radiographic imaging. If sinus disease is present, biopsy and culture
may lead to the diagnosis of fungal disease. Surgical debridement and
the appropriate systemic antifungal therapy usually lead to cure.