Sr. Thaller et al., EFFECT OF INSULIN-LIKE GROWTH-FACTOR TYPE-1 ON CRITICAL-SIZE DEFECTS IN DIABETIC RATS, The Journal of craniofacial surgery, 6(3), 1995, pp. 218-223
A number of investigators have reported on the clinically significant
relationship between diabetes mellitus and impaired wound healing. Dia
betic patients have an increased frequency of infection, delayed scar
formation, and poor bony union. Investigations completed in our labora
tory have demonstrated that insulin-like growth factor type 1 (IGF-1),
a somatomedin C, has shown promise for accelerating bony repair. The
purpose of this study was to examine the effects of recombinant IGF-1
on standardized, critical-size calvarial defects in 25 adult, male str
eptozocin-induced diabetic rats. From our study, it appears that IGF-1
exerts a potentiating effect on the repair of bony defects in diabete
s-induced rats.