IN-VIVO HUMAN MODELS FOR THE STUDY OF ANTICHOLINERGIC DRUGS

Background: The parasympathetic nervous system plays an important role in the nasal response to external stimuli. Objective: To review studi es showing the role of the parasympathetic nervous system in the nasal response and the effect of topical, intranasal anticholinergic agents on that response. Method: Literature review of in vivo human studies. Results: Nasal provocation with methacholine leads to glandular stimu lation. The response to methacholine provocation can be blocked by tre atment with ipratropium bromide. Stimulation of one nostril with hista mine, antigen, and cold, dry air leads to a bilateral secretory respon se that is partially inhibited by topical treatment with atropine. Con clusion: Topical anticholinergic agents should be useful in the reduct ion of glandular hypersecretion regardless of the etiology.