DIADENOSINE POLYPHOSPHATES - THEIR BIOLOGICAL AND PHARMACOLOGICAL SIGNIFICANCE

Diadenosine polyphosphates are members of a group of dinucleoside poly phosphates that are ubiquitous in bacteria to mammals. In recent years , the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmaco logical activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell prolifer ation and as signal molecules when cells are undergoing stress. Diaden osine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of th e diadenosine polyphosphates.