A NEW ROUTE TO 2'-C-METHYLENE NUCLEOSIDE ANALOGS, INHIBITORS OF RIBONUCLEOTIDE REDUCTASE

Authors
PONTIKIS R WOLF J MONNERET C FLORENT JC
Citation
R. Pontikis et al., A NEW ROUTE TO 2'-C-METHYLENE NUCLEOSIDE ANALOGS, INHIBITORS OF RIBONUCLEOTIDE REDUCTASE, Tetrahedron letters, 36(20), 1995, pp. 3523-3526
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
20
Year of publication
1995
Pages
3523 - 3526
Database
ISI
SICI code
0040-4039(1995)36:20<3523:ANRT2N>2.0.ZU;2-6
Abstract
Glycosyl phenyl sulfone obtained in 4 steps from isosaccharino-lactone was convened into a 2'-C-acetoxymethylfuranoid glycal with SmI2-HMPA. Coupling of this glycal with silylated thymine or cytidine in the pre sence of Pd(0) led after deprotection, to the 2'-deoxy-2'-methylidene- 5-methyluridine and to tire 2'-deoxy-2'-methylidene cytosine, respecti vely.