SYNTHESIS OF NEW ALPHA,ALPHA-DIFLUORO-GAMMA-LACTONES THROUGH INTRAMOLECULAR RADICAL CYCLIZATION AS A KEY REACTION

Authors
ITOH T OHARA H EMOTO S
Citation
T. Itoh et al., SYNTHESIS OF NEW ALPHA,ALPHA-DIFLUORO-GAMMA-LACTONES THROUGH INTRAMOLECULAR RADICAL CYCLIZATION AS A KEY REACTION, Tetrahedron letters, 36(20), 1995, pp. 3531-3534
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
20
Year of publication
1995
Pages
3531 - 3534
Database
ISI
SICI code
0040-4039(1995)36:20<3531:SONATI>2.0.ZU;2-X
Abstract
Carbon radicals from allyl ethylsilyl-alpha-bromo-alpha,alpha-difluoro acetals can cyclize onto olefines regiospecifically to give gamma-lact ols in good yield. These lactols have been converted to the correspond ing alpha,alpha-difluoro-gamma-lactones. The first synthesis of three new alpha,alpha-difluoro-gamma-lactones has been accomplished.