A novel molecularly imprinted polymer was prepared by copolymerization
of trimethylolpropane trimethacrylate (1) and methacrylic acid (3) in
the presence of a dipeptide acting as the template. The recognition c
apability of the synthetic receptor-like binding sites produced in the
polymer network for the peptide was demonstrated by using the polymer
as a chiral stationary phase in HPLC. The polymer was superior to pre
viously reported molecularly imprinted polymers in that unusually high
racemic resolution and load capacity were demonstrated.