SYNTHESIS AND CHARACTERIZATION OF POLYMERIC, ANIONIC THIOSALICYLATO-AG(I) COMPLEXES WITH ANTIMICROBIAL ACTIVITIES

Thiosalicylic acid ligand (H(2)TSA = o-HS(C6H4)COOH) forms two types o f anionic, light- and thermally stable Ag(I) complexes with remarkable antimicrobial activities for bacteria, yeast, and mold; one is a yell ow, water-soluble complex 1 and the other an orange, water-insoluble c omplex 2, either of which can be converted to the other, and both of w hich do to not crystallize. Both are complexes with composition of met al:TSA(2-) ligand = 1:1. The complex 2 is probably polymeric, whereas the complex 1 is an oligomer with a formula of {Na[Ag(TSA(2-)). H2O]}( n)(n = 12 - 14; MW = 3600 - 4200). Both complexes have been characteri zed with complete elemental analyses, TG/DTA, FT-IR, and ESCA spectra in the solid state, and complex 1 as well as with molecular weight mea surement in aqueous solution, and with Ag-109 and 2D NMR(H-1-H-1 COSY, H-1-C-13 COSY, and HMBC) measurements in aqueous solution.