Jm. Andrews et al., CONCENTRATIONS OF CEFTIBUTEN IN PLASMA AND THE RESPIRATORY-TRACT FOLLOWING A SINGLE 400 MG ORAL DOSE, International journal of antimicrobial agents, 5(2), 1995, pp. 141-144
Concentrations of ceftibuten in bronchial mucosa, epithelial lining fl
uid (ELF) and alveolar macrophages were determined from samples taken
from 15 subjects at bronchoscopy following a single 400 mg oral dose.
Concentrations at all sites were determined using a microbiological as
say method which was unaffected by the trans-isomer of ceftibuten. The
time from dosage to bronchoscopy ran ed from 1.4 to 20.3 h and the su
bjects were analysed in three groups according to time after dosing. G
roup A had a mean time since dosing of 1.9 h with mean serum, mucosal
and ELF concentrations of 15.2 mg/l, 5.7 mg/kg and 1.6 mg/l. Group B h
ad a mean time of 6.5 h after dosing with mean serum, mucosal and ELF
concentration of 14.0 mg/l, 3.2 mg/kg and 1.6 mg/l. Group C had a mean
time of 13.3 h with mean serum, mucosal and ELF levels of 4.1 mg/l, 1
.8 mg/kg and 1.2 mg/l. Macrophage-related ceftibuten could only be det
ected in two subjects. These levels are related to the minimum inhibit
ory concentrations of ceftibuten against common respiratory pathogens
with the exception of Strep. pneumoniae.