EFFECT OF A NEW NONSTEROIDAL ANTIINFLAMMATORY DRUG, NITROFLURBIPROFEN, ON THE EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN RAT NEUTROPHILS

Authors
MARIOTTO S CUZZOLIN L ADAMI A DELSOLDATO P SUZUKI H BENONI G
Citation
S. Mariotto et al., EFFECT OF A NEW NONSTEROIDAL ANTIINFLAMMATORY DRUG, NITROFLURBIPROFEN, ON THE EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN RAT NEUTROPHILS, British Journal of Pharmacology, 115(2), 1995, pp. 225-226
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
115
Issue
2
Year of publication
1995
Pages
225 - 226
Database
ISI
SICI code
0007-1188(1995)115:2<225:EOANNA>2.0.ZU;2-Y
Abstract
The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, a nd its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysacchari de administration, while flurbiprofen had no effect on nitric oxide sy nthase induction. This inhibitory action may be ascribed to nitric oxi de released from nitroflurbiprofen.