CONTROL OF THE REGIOSELECTIVITY OF N-NUCLEOPHILE ADDITION TO N-CARBONYL PROTECTED DEHYDROALANINES - A MODEL FOR THE AMMONIA-LYASE ENZYMES

Authors
GULZAR MS MORRIS KB GANI D
Citation
Ms. Gulzar et al., CONTROL OF THE REGIOSELECTIVITY OF N-NUCLEOPHILE ADDITION TO N-CARBONYL PROTECTED DEHYDROALANINES - A MODEL FOR THE AMMONIA-LYASE ENZYMES, Journal of the Chemical Society, Chemical Communications, (10), 1995, pp. 1061-1062
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
10
Year of publication
1995
Pages
1061 - 1062
Database
ISI
SICI code
0022-4936(1995):10<1061:COTRON>2.0.ZU;2-R
Abstract
The regioselectivity of the addition of N-nucleophiles to N-carbonyl p rotected dehydroalanine derivatives, beta-conjugate addition vs. alpha -imine capture, can be controlled completely by varying the N-protecti ng group, or, the carboxy protecting group thereby providing a model f or the chemistry of dehydroalanine residues within enzymes.