DYSGERMINOMA IN MOTHER AND DAUGHTER - USE OF LACTATE-DEHYDROGENASE ASA TUMOR-MARKER IN THE CHILD

A 7-year-old girl presented with an extragonadal dysgerminoma arising from the pelvis. Her mother had been treated for a histologically iden tical pituitary tumor 3 years previously. The child's serum lactate de hydrogenase (LDH) level was markedly elevated at presentation and fell as the tumor responded to treatment. The potential use of LDH as a ma rker for gonadal dysgerminoma is well documented, but raised LDH in as sociation with primary extragonadal dysgerminoma has not been describe d previously. In addition, this is the first report of extragonadal dy sgerminoma occurring in female relatives.