INCREASED PIVALOYLCARNITINE IN THE LIVER OF THE SODIUM PIVALATE TREATED RAT EXPOSED TO CLOFIBRATE

Authors
DIEP QN BOHMER T
Citation
Qn. Diep et T. Bohmer, INCREASED PIVALOYLCARNITINE IN THE LIVER OF THE SODIUM PIVALATE TREATED RAT EXPOSED TO CLOFIBRATE, Biochimica et biophysica acta, L. Lipids and lipid metabolism, 1256(2), 1995, pp. 245-247
Citations number
14
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, L. Lipids and lipid metabolism → ACNP
ISSN journal
00052760
Volume
1256
Issue
2
Year of publication
1995
Pages
245 - 247
Database
ISI
SICI code
0005-2760(1995)1256:2<245:IPITLO>2.0.ZU;2-#
Abstract
Clofibrate, a potent peroxisomal proliferator, increased the concentra tion of pivaloylcarnitine (nmol/g) in rat liver (mean +/- S.D.) from 1 1 +/- 1 (controls) to 213 +/- 39 (clofibrate), in heart from 348 +/- 1 07 to 521 +/- 41 and in brown adipose tissue from 185 +/- 52 to 184 +/ - 39 after administration of sodium pivalate. Clofibrate feeding incre ased the activity of carnitine acetyltransferase (U/mg) in liver (mean +/- S.D.) from 0.02 +/- 0.00 to 0.41 +/- 0.07 and decreased the triac ylglycerol concentration (mg/g liver, mean I S.D.) from 33.53 +/- 4.53 to 11.03 +/- 0.71.