IN-VITRO PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF 4 HUMAN PROSTATE-CANCER CELL-LINES

There is accumulating evidence that some biochemical pathways observab le by magnetic resonance spectroscopy, e.g., citrate acid and phosphol ipid metabolism, are altered in human prostate cancer. Four well-estab lished human prostate cancer cell lines were therefore studied with ma gnetic resonance spectroscopy to compare differences in metabolic cont ent with tumor biological behavior. Herein we demonstrate that, althou gh each cell line has its own metabolic profile, relative creatine and citrate levels can be used to discriminate the androgen-dependent LNC aP cell line from the androgen-independent DU-145, TSU, and PC-3 cell lines. (C) 1995 Wiley-Liss, Inc.