MAPPING OF GENE LOCI IN THE Q13-Q15 REGION OF CHROMOSOME-12

Authors
MITCHELL ELD WHITE GRM SANTIBANEZKOREF MF VARLEY JM HEIGHWAY J
Citation
Eld. Mitchell et al., MAPPING OF GENE LOCI IN THE Q13-Q15 REGION OF CHROMOSOME-12, Chromosome research, 3(4), 1995, pp. 261-262
Citations number
13
Categorie Soggetti
Biology
Journal title
Chromosome research → ACNP
ISSN journal
09673849
Volume
3
Issue
4
Year of publication
1995
Pages
261 - 262
Database
ISI
SICI code
0967-3849(1995)3:4<261:MOGLIT>2.0.ZU;2-W
Abstract
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in site hybridization ont o simultaneously DAPI-banded metaphase chromosomes and interphase nucl ei, we have more precisely mapped and ordered these loci, together wit h a number of Genethon microsatellite markers. GLI and CHOP localize t o 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene or der is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.