Gene therapy approaches have great promise in the treatment of neurode
generative disorders and malignant brain tumors. Neuwelt et al. review
available viral-mediated gene therapy methods and their blood-brain-b
arrier (BBB) disruption delivery technique, briefly mentioning nonvira
l mediated gene therapy methods. This commentary discussed the BBB dis
ruption delivery technique, viral and nonviral mediated gene therapy a
pproaches to Parkinson's disease, and the potential use of antisense o
ligo to suppress malignant brain tumors.