INTERACTION OF N-(2-HYDROXYBENZYL)-OMEGA-AMINO CARBONIC-ACIDS, NOVEL AMPHIPATHIC FATTY-ACID DERIVATIVES, WITH MEMBRANE - PARTITION-COEFFICIENTS

The methods for partition coefficient (K-p) determination were develop ed for different concentrations of N-(2-hydroxybenzyl)-omega-amino car bonic acids, a new class of amphipathic fatty acid derivatives (An), t heir deutero (AnD) and bromine (AnBr) derivatives. To do this the foll owing methods were used: H-2-NMR, equilibrium dialysis, centrifugation and fluorescence spectroscopy. K-p dependence on the An concentration is discussed. K-p values for AnBr were more than 120-times higher tha n those for An, the differences between them being smaller than those for the corresponding An. This series of new amphipathic compounds can be used as probes for membrane studies.