K. Komase et al., A COMPARISON OF NUCLEOTIDE-SEQUENCES OF MEASLES-VIRUS L-GENES DERIVEDFROM WILD-TYPE VIRUSES AND SSPE BRAIN-TISSUES, Virology, 208(2), 1995, pp. 795-799
The nucleotide sequences of the large protein (L) gene derived from tw
o wild-type measles viruses (MV) and two SSPE brain-derived viruses ha
ve been determined. All sequences have single large open reading frame
s encoding 2183 amino acid residues. The deduced L proteins are well c
onserved and the proposed functional domains which have been identifie
d for rhabdo- and paramyxoviruses are completely conserved in all stra
ins. The degree of variability of L proteins is the lowest of all stru
ctural proteins of MV, reflecting its role in virus reproduction and p
ersistence. Biased hypermutation was not observed in the L genes deriv
ed from SSPE brain tissue. None of the nucleotide changes can be assoc
iated with the attenuated phenotype of the Edmonston vaccine viruses.
(C) 1995 Academic Press, Inc.