CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF CISPENTACIN

Authors
THEIL F BALLSCHUH S
Citation
F. Theil et S. Ballschuh, CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF CISPENTACIN, Tetrahedron : asymmetry, 7(12), 1996, pp. 3565-3572
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
12
Year of publication
1996
Pages
3565 - 3572
Database
ISI
SICI code
0957-4166(1996)7:12<3565:CSOBEO>2.0.ZU;2-1
Abstract
Based on the lipase-catalysed kinetic resolution of the silyloxyalcoho l (1RS,2SR)-5 by transesterification with vinyl acetate in the presenc e of lipase from Pseudomonas cepacia a synthesis of both enantiomers o f the beta-amino acid cispentacin (1R,2S)-1 and (1S,2R)-1 using simple functional group interconversions is described. Copyright (C) 1996 El sevier Science Ltd.