THE CEPH CONSORTIUM LINKAGE MAP OF HUMAN-CHROMOSOME-11

The CEPH consortium framework map of chromosome 11 is presented. The m ap was generated from CEPH family DNAs with 181 probe/enzyme combinati ons contributed by 20 laboratories. Seventy-seven of the loci are defi ned by microsatellite polymorphisms that can be typed by the PCR. A to tal of 42 loci have been placed on the map with likelihood support of at least 1000:1. The female, male, and sex-average maps extend for 179 .6, 110.8, and 145.3 cM, respectively. The largest interval on the sex -average map is less than 11 cM, and the average distance between uniq uely placed loci is 4 cM. The genotypic data obtained for map construc tion have been used to identify the positions of crossovers on the chr omosomes of CEPH family children, allowing the localization of new mar kers without computationally intensive likelihood models and providing a basis for efficient extension of the linkage map to higher resoluti on. (C) 1995 Academic Press, Inc.