REDUCED RECRUITMENT OF INFLAMMATORY CELLS IN A CONTACT HYPERSENSITIVITY RESPONSE IN P-SELECTIN-DEFICIENT MICE

The inflammatory response at sites of contact hypersensitivity induced by oxazolone was examined in the ears of P-selectin-deficient and wil d-type mice. Accumulation of CD4(+) T lymphocytes, monocytes, and neut rophils was reduced significantly in the mutant mice, as well as mast cell degranulation. In contrast, there was no significant difference i n vascular permeability or edema between the two genotypes. The result s demonstrate a role for P-selectin in recruitment of CD4(+) T lymphoc ytes and show that P-selectin plays a role in long-term inflammation a s well as in acute responses.