OLIGOSACCHARIDES RELATED TO TUMOR-ASSOCIATE ANTIGENS .4. MODELING OF THE TERMINAL TETRASACCHARIDE OF AN ANTIGEN RECOGNIZED BY THE MBR1 ANTIBODY AND OF OVERLAPPING DISACCHARIDE AND TRISACCHARIDE SEQUENCES

Authors
TOMA L COLOMBO D RONCHETTI F PANZA L RUSSO G
Citation
L. Toma et al., OLIGOSACCHARIDES RELATED TO TUMOR-ASSOCIATE ANTIGENS .4. MODELING OF THE TERMINAL TETRASACCHARIDE OF AN ANTIGEN RECOGNIZED BY THE MBR1 ANTIBODY AND OF OVERLAPPING DISACCHARIDE AND TRISACCHARIDE SEQUENCES, Helvetica Chimica Acta, 78(3), 1995, pp. 636-646
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
78
Issue
3
Year of publication
1995
Pages
636 - 646
Database
ISI
SICI code
0018-019X(1995)78:3<636:ORTTA.>2.0.ZU;2-G
Abstract
The conformational space of the tetrasaccharide alpha-L-Fuc-(1 --> 2)- beta-D-Gal-(1 --> 3)-beta-D-GalNAc-(1 --> 3)-alpha -D-Gal1Pr (3) and o f some overlapping di- and trisaccharide sequences was investigated wi th the aid of molecular-mechanics energy minimizations, molecular-dyna mics simulations, and H-1-NMR analysis. These investigations suggested that in compound:) a certain rigidity of the first two glycosidic lin kages (Fuc-Gal and Gal-GalNAc) is combined with the flexibility of the third one (GalNAc-Gal).