Ph. Aguiar et al., PROLIFERATIVE ACTIVITY OF ACOUSTIC NEURILEMOMAS WITHOUT NEUROFIBROMATOSIS DETERMINED BY MONOCLONAL-ANTIBODY MIB-1, Acta neurochirurgica, 134(1-2), 1995, pp. 35-39
Microscopic sections obtained from paraffin blocks of 30 consecutive n
eurilemomas stored in 1989 were investigated immunohistochemically wit
h the new monoclonal antibody MIB 1 directed against recombinant parts
of Ki-67 antigen. The immunohistochemical staining was carried out on
dewaxed microwave-oven-processed paraffin sections of formalin-fixed
tumour tissues. The labelling index (LI) obtained was below 1% in 21 c
ases, 1-3% in 7 cases and more than 3% in 2 cases. There was no correl
ation between the LI and the age of the patients or the tumour size. T
he major advantage of MIB 1 over previous immunohistochemical methods
is its usefullness in long preserved sections which are ideal for retr
ospective studies.