Mp. Trova et Kf. Mcgee, ASYMMETRIC-SYNTHESIS OF OPTICALLY-ACTIVE DECAHYDROISOQUINOLINES USEFUL IN HIV-1 PROTEASE INHIBITOR SYNTHESIS, Tetrahedron, 51(21), 1995, pp. 5951-5954
An efficient synthesis of amino acid ester 8 is described featuring an
asymmetric aza-Diels-Alder reaction of diene 5 and chiral imine 6 whi
ch establishes the asymmetry at C-3. Hydrogenation of 7 provides 8 wit
h the desired asymmetry at C-4a and C-8a.