MAPPING OF THE CONGENITAL GENERALIZED HYPERTRICHOSIS LOCUS TO CHROMOSOME XQ24-Q27.1

Congenital generalized hypertrichosis (CGH) is a rare, fully penetrant X-linked dominant trait previously described in a single, multigenera tional Mexican family. CGH is a visually striking phenotype characteri zed by excessive facial and upper torso hair in males and by less seve re asymmetric hairiness in females. We have found significant evidence for linkage with several markers from the long arm of the X chromosom e. Recombinant chromosomes place the CGH gene within a 22 cM interval between DXS425 and DXS1227 in Xq24-Xq27.1. The localization of a gene for CGH represents the first step towards the isolation of genes invol ved in hair growth pattern, particularly those involved in restriction of areas in humans.