NESIDIOBLASTOSIS ASSOCIATED WITH HYPERGLYCEMIA IN 2 SQUIRREL-MONKEYS (SAIMIRI-SCIUREUS)

Nesidioblastosis associated with progressive weight loss and hyperglyc emia was diagnosed in two mid-adult, wild-caught, male squirrel monkey s (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hyp othermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained pre dominantly glucagon-positive in the most severely affected monkey.