POLAROGRAPHIC AND VOLTAMMETRIC BEHAVIOR OF OFLOXACIN AND ITS ANALYTICAL APPLICATION

The polarographic and voltammetric behaviour of ofloxacin was studied by various electrochemical methods. A well-defined linear-sweep voltam metric peak was obtained at -1.343 V (vs. saturated calomel electrode) in Britton-Robinson buffer (pH 4.00). The characteristics of the peak have been examined in detail. The experimental results prove that the reduction of ofloxacin is irreversible and that the peak has adsorpti on characteristics. A mechanism is proposed for the reduction of the s ample. The peak current (i'(P)) is proportional to the concentration o ver the range 8 X 10(-4)-2 X 10(-5) mol l(-1) and the limit of detecti on is 4 X 10(-6) mol l(-1). A single-sweep oscillopolarographic method was developed for the determination of ofloxacin in pharmaceutical fo rmulations. The mean recovery of ofloxacin was 101.0% with an relative standard deviation of 2.2%.