Mal. Nicolelis et al., SENSORIMOTOR ENCODING BY SYNCHRONOUS NEURAL ENSEMBLE ACTIVITY AT MULTIPLE LEVELS OF THE SOMATOSENSORY SYSTEM, Science, 268(5215), 1995, pp. 1353-1358
Neural ensemble processing of sensorimotor information during behavior
was investigated by simultaneously recording up to 48 single neurons
at multiple relays of the rat trigeminal somatosensory system. Cortica
l, thalamic, and brainstem neurons exhibited widespread 7- to 12-hertz
synchronous oscillations, which began during attentive immobility and
reliably predicted the imminent onset of rhythmic whisker twitching.
Each oscillatory cycle began as a traveling wave of neural activity in
the cortex that then spread to the thalamus. Just before the onset of
rhythmic whisker twitching, the oscillations spread to the spinal tri
geminal brainstem complex. Thereafter, the oscillations at all levels
were synchronous with whisker protraction. Neural structures manifesti
ng these rhythms also exhibited distributed spatiotemporal patterns of
neuronal ensemble activity in response to tactile stimulation, thus,
multilevel synchronous activity in this system may encode not only sen
sory information but also the onset and temporal domain of tactile exp
loratory movements.