PGE(2) INVOLVEMENT IN EXPERIMENTAL-INFECTION WITH TRYPANOSOMA-CRUZI SUBPOPULATIONS

PGE(2) involvement in experimental Trypanosoma cruzi infection depends on the lethal capacity of the parasite subpopulation used. Mice acute ly infected with non-lethal K98 displayed an enhancement in PGE(2) ser um levels during the acute period, while those infected with lethal T, cruzi subpopulations (RA or K98-2) showed levels not different from n ormal mice. The enhancement detected in K98 group could be related bot h to an increased number of CD8+ T cell number and to enhanced PGE(2) release per cell by CD8+; values of PGE(2) release by adherent cells w ere not altered in this group. Treatment with cyclooxygenase inhibitor s enhanced mortality rates of mice infected with K98, and administrati on of 16,16-dimethyl PGE(2) (dPGE) reversed this effect. However, mice infected with RA did not reduce their mortality rates by administrati on of diverse doses of dPGE. These findings suggest that PGE(2) could play a role in resistance in mice infected with K98.