B-CELL SUPPRESSOR FACTOR (BSF) AND ERYTHR OBLAST SUPPRESSOR FACTOR (ERSF) EFFECT ON HEMATOPOIETIC PRECURSOR COLONY-FORMING CAPACITIES

Hemopoietic precursor cloning in healthy,donors and patients with lymp hoproliferative disorders and its regulation in donors by two novel su ppressive factors (BSF and ErSF) are investigated. It is shown that th e count of erythroid precursors is increased in peripheral blood of pa tients with non-Hodgkin's lymphoma in contrast to the count of granulo cyte-macrophage precursors. BSF inhibits entirely granulocyte-macropha ge, macrophage and erythrocyte colony growth. In contrast, ErSF abroga tes selectively erythroid precursor cell proliferation and differentia tion. The role of the above factor in normal hemopoiesis inhibition me chanism during lymphoproliferative diseases are discussed.