ACTIVITY OF ECDYSONE ANALOGS IN ENHANCING N-ACETYLGLUCOSAMINE INCORPORATION INTO THE CULTURED INTEGUMENT OF CHILO-SUPPRESSALIS

Ecdysone analogs with various side chains at the 17-position of the st eroid structure enhanced the incorporation of N-acetylglucosamine as 2 0-hydroxyecdysone into the cultured integument prepared from Chilo sup pressalis. Their activity in terms of the concentration required to gi ve 50% of the maximum response varied with the structure. Piperonyl bu toxide, an inhibitor of oxidation metabolism, did not enhance the in v itro effect of the compounds. The order of potency was ponasterone A > 20-hydroxyecdysone > cyasterone > inokosterone > makisterone A >> ecd ysone.