A SIMPLE SYNTHESIS OF 11,19-OXIDOSTEROIDS

Authors
BOUDI A ZAPARUCHA A GALONS H CHIADMI M VIOSSAT B TOMAS A FIET J
Citation
A. Boudi et al., A SIMPLE SYNTHESIS OF 11,19-OXIDOSTEROIDS, Steroids, 60(5), 1995, pp. 411-413
Citations number
9
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
60
Issue
5
Year of publication
1995
Pages
411 - 413
Database
ISI
SICI code
0039-128X(1995)60:5<411:ASSO1>2.0.ZU;2-C
Abstract
The photochemical hypoiodination of cortisol acetonide gave a mixture of 18-iodocortisol acetonide and of the 11 beta,19-oxidoderivative. Th e proportion of the two products was slightly modified by the reaction temperature. Deprotection of the acetonide group of the 11 beta,19-ox idoderivative gave 11 beta,19-oxido-17 alpha,21-dihydroxy-4-pregnen-3, 20-dione which led to the formation of 11 beta,19-oxido-4-androsten-3, 17-dione upon treatment with sodium bismutate.