Cr. Noe et al., AMINOALCOHOLS .3. PREPARATION OF ENANTIOM ERICALLY PURE PHARMACOLOGICALLY ACTIVE N-SUBSTITUTED BETA-AMINOALCOHOLS, Monatshefte fuer Chemie, 126(5), 1995, pp. 557-564
A synthesis of N-substituted beta-aminoalcohols is described starting
from enantiomerically pure O-MBF- or O-MBE-protected beta-aminoalcohol
s which can be prepared via LiAlH4 reduction of O-protected cyanohydri
nes.