TEMPORAL VARIATION IN HEPATIC SUPEROXIDE-DISMUTASE ACTIVITY IN MICE

Authors
HODOGLUGIL U ONGUN O GUNEY Z ALTAN N ZENGIL H
Citation
U. Hodoglugil et al., TEMPORAL VARIATION IN HEPATIC SUPEROXIDE-DISMUTASE ACTIVITY IN MICE, Chronobiology international, 12(2), 1995, pp. 152-155
Citations number
15
Categorie Soggetti
Physiology,"Biology Miscellaneous
Journal title
Chronobiology international → ACNP
ISSN journal
07420528
Volume
12
Issue
2
Year of publication
1995
Pages
152 - 155
Database
ISI
SICI code
0742-0528(1995)12:2<152:TVIHSA>2.0.ZU;2-M
Abstract
Circadian variations in superoxide dismutase (SOD) activity were deter mined in liver homogenates of Balb-C mice that were synchronized under controlled environmental conditions with 12 h light:12 h dark. The ac tivity of hepatic SOD exhibited a significant circadian rhythm, with a minimum at 01:00 h and maximum at 10:00-13:00 h. It is concluded that fluctuations in hepatic SOD activity render mice more susceptible to the toxic effects of reactive oxygen radicals at particular times of t he day.