PREPARATION AND IN-VITRO ACTIVITY OF ARYL ETHER DERIVATIVES OF THE FK-506 RELATED IMMUNOSUPPRESSIVE MACROLIDES ASCOMYCIN AND L-683,742

Authors
SINCLAIR PJ WONG F WYVRATT M STARUCH MJ DUMONT F
Citation
Pj. Sinclair et al., PREPARATION AND IN-VITRO ACTIVITY OF ARYL ETHER DERIVATIVES OF THE FK-506 RELATED IMMUNOSUPPRESSIVE MACROLIDES ASCOMYCIN AND L-683,742, Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1035-1038
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1035 - 1038
Database
ISI
SICI code
0960-894X(1995)5:10<1035:PAIAOA>2.0.ZU;2-9
Abstract
The arylation of the immunosuppressive macrolides ascomycin and L-683, 742 using pentavalent bismuth reagents is described. The in vitro acti vities of the aryl ether analogs are reported.