MECHANISTIC SUPPORT FOR THE STEPWISE PROCESS FOR INACTIVATION OF CLASS-A BETA-LACTAMASES BY CLAVULANATE

Authors
MIYASHITA K MOBASHERY S
Citation
K. Miyashita et S. Mobashery, MECHANISTIC SUPPORT FOR THE STEPWISE PROCESS FOR INACTIVATION OF CLASS-A BETA-LACTAMASES BY CLAVULANATE, Bioorganic & medicinal chemistry letters, 5(10), 1995, pp. 1043-1048
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
10
Year of publication
1995
Pages
1043 - 1048
Database
ISI
SICI code
0960-894X(1995)5:10<1043:MSFTSP>2.0.ZU;2-2
Abstract
We proposed recently a stepwise process for the inactivation chemistry of class A beta-lactamases by clavulanate (J. Am. Chem. Sec. 1993, 11 5, 4435). A requisite protonation by an active-site water molecule was suggested to be a critical chemical step in enzyme inactivation. The details of this proposed stepwise mechanism have been explored further by three synthetic analogues of clavulanate.